Edwardsiella tarda is a rare human causative bacterium, especially in extraintestinal infections. In this study, we described a case of E. tarda and Proteus vulgaris coinfection in a fish vendor who suffered a work-related injury during fish butchering. In this patient, E. tarda and P. vulgaris were resistant to several antibiotics, including ampicillin, colistin, trimethoprim-sulfamethoxazole, cefazolin, ceftriaxone, amikacin, cefepime, ciprofloxacin, ampicillin-sulbactam, and tigecycline. The patient was managed by necrotic tissue debridement, vacuum-assisted closure, skin grafting, and antibiotic treatment. After 2 weeks, the wound healed completely. To the best of our knowledge, this was the first case report of extraintestinal infection caused by multidrug-resistant E. tarda.